"I will end my athletic career and formally retire from the game of basketball," Yao Ming, who turns 31 in September, told a packed press conference in his hometown.
The Shanghai native, who stands at 7 feet and 6 inches (2.29 meters), blamed persistent injuries for cutting short his decorated career on the court.
"At the end of last year, I once again had a stress fracture in my left foot and had to sit out of basketball," he said. "Since then, like many friends who cared about me, I waited and hoped that I could return."
The nicknamed "Little Giant" was signed by the Houston Rockets in 2002 as the top overall pick of the National Basketball Association in North America.